“Hot cross bun” is a potential imaging marker for the severity of cerebellar ataxia in MSA-C

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The hot cross bun sign.

Hot cross bun sign refers to the cruciform-shaped hyperintensity on T2W axial magnetic resonance images (MRI) in multisystem atrophy due to the selective loss of myelinated transverse pontocerebellar fibers and neurons in the pontine raphe and sparing of the pontine tegmentum and corticospinal tracts [Figure 1, Figure 2].[1] The name derives from a sweet spiced bun baked by the Christian church...

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"Hot cross bun" sign in two patients with multiple system atrophy-cerebellar.

The “hot cross bun” sign is characterized by cross-shaped T2 signal hyperintensity within the pons and has been said to be specific although not pathognomonic for multiple system atrophy (MSA).1 Case 1 is a 60-year-old woman who presented with progressive spasticity, limb ataxia, and urinary incontinence of 3 1⁄2 years’ duration (figure 1). Case 2 is a 56-year-old man, who had a history of urge...

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Hot cross bun sign in a case with multisystem atrophy

A 65-year-old man came to our clinic with progressive disequilibrium and gait problem since 6 years. During this period, he had also urinary incontinency. On neurologic examination, he had scanning speech and bidirectional nystagmus. There was hypokinesia in upper and lower limbs and on cerebellar tests finger to nose and heel to shin were impaired (severe dysmetria); he was unable to walk with...

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ژورنال

عنوان ژورنال: npj Parkinson's Disease

سال: 2021

ISSN: 2373-8057

DOI: 10.1038/s41531-021-00159-w